Glutathione Reductase and Thioredoxin Reductase: Novel Antioxidant Enzymes from Plasmodium berghei

Glutathione reductase and thioredoxin reductase: novel antioxidant enzymes from Plasmodium berghei.

Malaria parasites adapt to the oxidative stress during their erythrocytic stages with the help of vital thioredoxin redox system and glutathione redox system. Glutathione reductase and thioredoxin reductase are important enzymes of these redox systems that help parasites to maintain an adequate intracellular redox environment. In the present study, activities of glutathione reductase and thiore...

Thioredoxin Reductase is More Effective than Glutathione Reductase in Inducing Protection against Plasmodium Berghei Infection

Thioredoxin reductase and glutathione reductase are important enzymes of redox system that help the malaria parasite to maintain an adequate intracellular redox environment and contribute greatly to the antioxidant capacity of the cell. In the present study humoral immune response directed against thioredoxin reductase and glutathione reductase during Plasmodium berghei infection were investiga...

Dihydrofolate reductase from pyrimethamine-resistant Plasmodium berghei.

An investigation of the Hz-folate reductases from pyrimethamine-sensitive (Pb/WLTM) and -resistant (Pb/ WLTM/50-63) strains of Plasmodium berghei has revealed that the specific activity of the enzyme from the resistant strain is IO-fold higher than that of the sensitive strain. Since turnover numbers (based on amethopterin binding) are equivalent, the increase in specific activity must be due t...

Mammalian Selenoprotein Thioredoxin-glutathione Reductase

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis. Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an N...